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apalutamide will lower the extent or outcome of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with prescription drugs which have been CYP3A4 substrates may result in decrease exposure to those medicines.In one-evening, double-blind,